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KMID : 1211620180130010011
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Journal of the Korean Society of Physical Medicine
2018 Volume.13 No. 1 p.11 ~ p.26
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Exercise Intervention on Blood Glucose Control of Type 2 Diabetes with Obesity : A Systematic Review
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Jung Su-Ryun
Kim Wan-Soo
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Abstract
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PURPOSE: The aim of this study was to review the effects of exercise intervention on blood glucose control in obese type 2 diabetic patients.
METHODS: The PubMed and KERISS search engines were used and 61 papers that met the key questions were selected.
RESULTS: Exercise is an effective intervention for the control of blood glucose in type 2 diabetic patients because it does not impair glucose transport in the skeletal muscle induced by muscle contractions. Insulin resistance, which is characteristic of type 2 diabetes, is caused by decreased insulin sensitivity or insulin responsiveness. Acute exercise improves the glucose metabolism by increasing the insulin-independent signaling pathways and insulin sensitivity in the skeletal muscle, and regular long-term exercise improves the skeletal muscle insulin responsiveness and systemic glucose metabolism by increasing the mitochondrial and GLUT4 protein expression in the skeletal muscle.
CONCLUSION: The improvement of the glucose metabolism through exercise shows a dose-response pattern, and if exercise consumes the same number of calories, high intensity exercise will be more effective for the glucose metabolism. On the other hand, it is practically difficult for a patient with obese type 2 diabetes to control their blood glucose with high intensity or long-term exercise. Therefore, it will be necessary to study safe adjuvants (cinnamic acid, lithium) that can produce similar effects to high-intensity and high-volume exercises in low-intensity and low-volume exercises.
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KEYWORD
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Exercise, Insulin responsiveness, Insulin sensitivity, Obesity, Type 2 diabetes
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